Autoimmune Hepatitis And Primary Sclerosing Cholangitis – Overlap Syndrome

Autoimmune hepatitis (AIH) usually exists as a single entity but rarely occurs in combination with either primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC) as a part of an overlap syndrome. Each of these overlap syndromes has its own characteristic features. We report on a case of autoimmune hepatitis with subsequent development of primary sclerosing cholangitis and ulcerative colitis. Identification of patients with overlap syndrome is important as they typically have a poorer response to steroid therapy, enter remission less frequently and fail therapy more commonly.