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A comparison of the respiratory depressant effects of dextropropoxyphene and codeine in man

J. Weldon Bellville, John C. Seed

Open publisher page 14 citations

Abstract

Twelve volunteers were given placebo and graded doses of codeine and dextropropoxyphene to determine the relative respiratory potency of oral dextropropoxyphene and oral codeine. Carbon dioxide response curves were prepared from data accumulated with a rebreathing technique. The relative respiratory potency, p, was calculated as 0.33. According to this calculation, 180 mg. of dextropropoxyphene administered orally produces respiratory depression equal to that of 60 mg. of codeine orally.

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What this paper is about

Twelve volunteers were given placebo and graded doses of codeine and dextropropoxyphene to determine the relative respiratory potency of oral dextropropoxyphene and oral codeine. Carbon dioxide response curves were prepared from data accumulated with a rebreathing technique. The relative respiratory potency, p, was calculated as 0.33. According to this calculation, 180 mg. of dextropropoxyphene administered orally produces respiratory depression equal to that of 60 mg. of codeine orally.

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Available abstract

Twelve volunteers were given placebo and graded doses of codeine and dextropropoxyphene to determine the relative respiratory potency of oral dextropropoxyphene and oral codeine. Carbon dioxide response curves were prepared from data accumulated with a rebreathing technique. The relative respiratory potency, p, was calculated as 0.33. According to this calculation, 180 mg. of dextropropoxyphene administered orally produces respiratory depression equal to that of 60 mg. of codeine orally.

Key concepts: Propoxyphene, Codeine, Potency, Placebo, Depressant, Respiratory system, Anesthesia, Analgesic

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