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[Influence of the inoculum effect on the MIC and MBC of 5 beta-lactams against Pseudomonas aeruginosa].

J. Croizé, Le Noc P, J. Robert

Abstract

MICs and MBCs of five beta-lactams , i.e. ticarcillin, azlocillin, piperacillin, cefsulodin and ceftazidime for 20 strains of Pseudomonas aeruginosa were studied with inocula ranging from 10(3) to 10(9) CFU/ml. Each antibiotic exhibited an inoculum effect at 10(5)-10(7) CFU/ml. However, ticarcillin had smaller MIC and MBC increments than the four other drugs, making it more suitable in certain cases.

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Key concepts: Azlocillin, Ticarcillin, Cefsulodin, Piperacillin, Pseudomonas aeruginosa, Microbiology, Ceftazidime, Chemistry