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Regulation of brown adipose tissue thermogenesis by corticosterone in obese fa/fa rats.

York Da, Holt Sj, Jackie Marchington

Abstract

The defective BAT function of obese Zucker rats has been related primarily to a loss of diet-induced thermogenesis. The normalisation of BAT function by adrenalectomy has been related to the removal of corticosterone. Experiments with propranolol-blockade and on tissue norepinephrine turnover suggest that corticosterone impairs diet-related sympathetic activity but does not alter BAT response to exogenous norepinephrine. The reduction in serum T3 in obese rats is related to the loss of sympathetic activity.

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Key concepts: Thermogenesis, Brown adipose tissue, Endocrinology, Internal medicine, Corticosterone, Norepinephrine, Adrenalectomy, Propranolol