1996•PubMedRequires access

[D1 receptor mediates dopamine-induced enhancement of electroretinographic oscillatory potentials].

Shigeki Tagawa, Y Shirao, Takahiko Tamura, Akiko Kobayashi, Kaoru Katoh

Abstract

The inhibitory action of SCH 23390 (SCH, D1-antagonist) or sulpiride (SUL, D2-antagonist) on the dopamine-induced enhancement of the electroretinographic oscillatory potentials was examined in anesthetized albino rabbits. Enhancement of the oscillatory potentials by intravitreal dopamine (50 microM intravitreal concentration) injection was blocked by a simultaneous intravitreal injection of SCH (20 microM) but not by SUL (50 microM, 100 microM). These results suggest that D1-receptor is mainly responsible for the dopamine-induced enhancement of the oscillatory potentials.

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Key concepts: Sulpiride, SCH-23390, Dopamine, Dopamine antagonist, Antagonist, Dopamine receptor, Dopamine receptor D2, Chemistry