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[Characteristics of genotoxic and carcinogenic action of metals].

Maksimchuk Tp, Babenko Ga

Abstract

The data on carcinogenic activity of certain metals and their compounds to humans and experimental animals are reviewed. Cellular uptake and intracellular distribution of metal compounds, metal-induced genotoxicity in different short-term tests are described. Specific lesions of DNA produced by carcinogenic metals, the influence of metal ions on the cell growth, DNA replication and DNA repair involved in mutagenesis and oncogenesis are under discussion. Mechanisms of metal carcinogenesis are studied to a less extent as compared with organic carcinogenesis.

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Key concepts: Carcinogen, Carcinogenesis, Genotoxicity, Mutagenesis, DNA, Metal, Chemistry, DNA damage