2004•PubMedRequires access
[Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey].
Ningshao Xia, Jun Zhang, Ying-jie Zheng, Yan Qiu, Shengxiang Ge, Xiangzhong Ye, Shan-Hai Ou
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Abstract
OBJECTIVE: To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals. METHODS: RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity. RESULTS: Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data. CONCLUSION: Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E