[Effect of Bencyclane on regional cerebral circulation. Quantitative local measurement of cerebral circulation in healthy persons and patients with cerebrovascular insufficiency, awake or in light general anesthesia].

The effect of intravenous continuous drip infusion of Bencyclan (8mg/min) on regional cerebral blood flow was investigated in 30 adult patients, using the intraarterial 133-Xe-clearance-method and a 10-detector-equipment. The application of Bencyclan in 5 persons with normal cerebral circulation entailed no significant change of rCBF. In 5 from 15 patients with cerebrovascular disease in the awake state continuous drip infusion of Bencyclan caused a decrease of global and regional cerebral blood flow with reduction of the regional flow values about 15.3 to 28.4 p.c. In 10 patients there was seen no statistical significant change of regional cerebral blood flow as compared with the flow values in the resting state. In 10 patients rCBF-examinations were performed prior and after intravenous injection of Bencyclan in a state of a very light nitrous-oxide-halothan analgesia. In all patients Bencyclan caused an overall decrease of cerebral blood flow about 8.8 p.c. to 24.3 p.c. which in 5 cases achieved statistical significance.