1993•American Journal of HypertensionRequires access

Synergistic Action of Angiotensin II, Insulin- Like Growth Factor-I, and Transforming Growth Factor-β on Platelet-Derived Growth Factor-BB, Basic Fibroblastic Growth Factor, and Epidermal Growth Factor-Induced DNA Synthesis in Vascular Smooth Muscle Cells

Yon D. Ko, Heike Stiebler, Georg Nickenig, Andreas J. Wieczorek, Hans Vetter, Agapios Sachinidis

Abstract

The effect of angiotensin II (AII), transforming growth factor-beta (TGF-beta), and insulin-like growth factor-I (IGF-I) on platelet-derived growth factor (PDGF)-BB-, basic fibroblastic growth factor (bFGF)-, and epidermal growth factor (EGF)-induced DNA synthesis in vascular smooth muscle cells (VSMCs) was investigated. TGF-beta, AII, IGF-I increased concentration-dependent cell protein. No increase in [3H]thymidine incorporation could be detected. TGF-beta, AII, and IGF-I enhanced PDGF-BB-, bFGF-, and EGF-induced DNA synthesis. Our results suggest that growth factors that possess a weak mitogenic effect on vascular smooth muscle cells such as TGF-beta, AII, and IGF-I may enhance the mitogenicity of PDGF-BB, bFGF, and EGF.

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Key concepts: Growth factor, Platelet-derived growth factor, Epidermal growth factor, Endocrinology, Platelet-derived growth factor receptor, Internal medicine, DNA synthesis, Transforming growth factor