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Improvement in the yield of oral poliovirus vaccine (Sabin strains) produced in human diploid cells.

Hossein Mirchamsy, S Shafyi, S. Bahrami, M Kamali, P. Nazari, M. Mahinpour

Abstract

When stationary cultures of human diploid cells in conventional Roux bottles were replaced by the development of cells in roller bottles, the yield of poliovirus, Sabin strains type 1 and 2, showed an increase of 0.5 to 1 log10. No significant difference was noticed in the yield of these viruses cultured in WI-38 and MRC-5 human diploid cells.

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Key concepts: WI-38, Ploidy, Poliovirus, Yield (engineering), Biology, Virology, Microbiology, Food science