[Morphological characteristics of the testicles of male Wistar rats intoxicated with morphine].

Experimental study of the effect of morphine on reproductive organs was made in Wistar rats. In the experimental animals from Group 1, 1% morphine solution was intraperitoneally injected in increasing doses during 10 days while in Group 2 animals were taught to administer morphine themselves during 28 days. Morphological and morphometric studies were conducted. The plasma levels of follicle-stimulating hormone, luteinizing hormone, corticosterone, testosterone, and estradiol were measured by enzyme immunoassay. It was ascertained that there was a progressive inhibition of both hormonopoietic and spermatogenic functions depending on the duration of morphine use.