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[The change of alveolar fluid clearance in acute lung injury rat].

Zhiwei Chen, Chunxue Bai, Xiaohui Fang

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Abstract

OBJECTIVE: To establish the animal model of lung injury caused by hydrochloric acid in rats, measure the alveolar fluid clearance (AFC) in different acidic condition. METHODS: 32 rats were randomly divided into 4 groups which were control group (pH = 7.4) and HCl groups (pH = 7.0, 4.5, 2.5). The animals were anesthetized and ventilated for 1 hour. Blood gas analysis was performed, then the permeability of lung epithelial barrier and AFC were measured. RESULTS: The permeability of lung epithelial barrier, PaO(2) and AFC of pH 7.0 group were similar to control group (P > 0.05), but declined in pH 4.5 and 2.5 groups (P < 0.05). CONCLUSIONS: The alveolar epithelium and the alveolar epithelial barrier are resistant to the injurious effects of acid, but high concentration acid can induce damage.

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What this paper is about

OBJECTIVE: To establish the animal model of lung injury caused by hydrochloric acid in rats, measure the alveolar fluid clearance (AFC) in different acidic condition. METHODS: 32 rats were randomly divided into 4 groups which were control group (pH = 7.4) and HCl groups (pH = 7.0, 4.5, 2.5). The animals were anesthetized and ventilated for 1 hour. Blood gas analysis was performed, then the permeability of lung epithelial barrier and AFC were measured. RESULTS: The permeability of lung epithelial barrier, PaO(2) and AFC of pH 7.0 group were similar to control group (P > 0.05), but declined in pH 4.5 and 2.5 groups (P < 0.05). CONCLUSIONS: The alveolar epithelium and the alveolar epithelial barrier are resistant to the injurious effects of acid, but high concentration acid can induce damage.

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Available abstract

OBJECTIVE: To establish the animal model of lung injury caused by hydrochloric acid in rats, measure the alveolar fluid clearance (AFC) in different acidic condition. METHODS: 32 rats were randomly divided into 4 groups which were control group (pH = 7.4) and HCl groups (pH = 7.0, 4.5, 2.5). The animals were anesthetized and ventilated for 1 hour. Blood gas analysis was performed, then the permeability of lung epithelial barrier and AFC were measured. RESULTS: The permeability of lung epithelial barrier, PaO(2) and AFC of pH 7.0 group were similar to control group (P > 0.05), but declined in pH 4.5 and 2.5 groups (P < 0.05). CONCLUSIONS: The alveolar epithelium and the alveolar epithelial barrier are resistant to the injurious effects of acid, but high concentration acid can induce damage.

Key concepts: Alveolar Epithelium, Lung, Chemistry, Hydrochloric acid, Permeability (electromagnetism), Pathology, Epithelium, Anesthesia

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