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[The in vitro liberation behavior of quinidine from drug forms with prolonged release by various liberation methods].

Bernd K. Appelt, D. Hennig, Ulrich Wenzel

Abstract

The liberation behaviour of the following preparations were tested using two models: Chinidin-Duriles (Astra, Sweden), Chinidin-longo (VEB Isis-Chemie Zwickau, GDR), Chinidin-retard-Isis (VEB Isis-Chemie Zwickau, GDR). The received data were estimated by multivariate statistical methods. It was found, that the three tested preparations are different in their liberation behaviour. Moreover it was shown, that there are differences between the two apparatus. Nevertheless both methods are able to characterize the liberation behaviour of the three preparations.

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Available abstract

Key concepts: Liberation, Chemistry, Quinidine, Pharmacology, In vitro, Medicine, Biochemistry