1992•PubMedRequires access

Species differences in platelet aggregation induced by platelet-activating factor (PAF).

Koji Shinozaki, Tomio Kawasaki, Junichi Kambayashi, Masato Sakon, Eiichi Shiba, Ming-Che Ou, Takahiro Mori

Abstract

Species differences in platelet aggregation induced by platelet-activating factor (PAF) were investigated by using the same procedure of platelet preparation and biological assay. Washed platelets of six different species (horses, dogs, rats, rabbits, sheep and guinea pigs) were prepared employing the same method and platelet aggregation was induced by C16-PAF. Horse platelets were most sensitive to PAF (8.0 x 10(-12) M) and rabbit platelets activated by 5.0 x 10(-11) M PAF were also sensitive enough to detect PAF in clinical samples.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 12 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Platelet-activating factor, Platelet, Chemistry, Platelet aggregation, Guinea pig, Horse, Platelet activation, Pharmacology