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Influence of pretreatment with disulfiram (DSF) on the acute toxicity of cyclophosphamide (CP) in male Sprague-Dawley rats.

H Habs, M. Habs, Dieter Schmähl

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Abstract

Treatment with disulfiram (DSF, 1000 mg/kg p.o.) 2 or 6 h prior to s.c. injection of cyclophosphamide (CP) raised the acute toxicity of CP in male Sprague-Dawley rats by 60%. The acute LD50 was reduced from 236 mg/kg after application of CP alone to 90 mg/kg and 95 mg/kg after pretreatment with DSF 2 and 6 h prior to CP administration, respectively.

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What this paper is about

Treatment with disulfiram (DSF, 1000 mg/kg p.o.) 2 or 6 h prior to s.c. injection of cyclophosphamide (CP) raised the acute toxicity of CP in male Sprague-Dawley rats by 60%. The acute LD50 was reduced from 236 mg/kg after application of CP alone to 90 mg/kg and 95 mg/kg after pretreatment with DSF 2 and 6 h prior to CP administration, respectively.

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Available abstract

Treatment with disulfiram (DSF, 1000 mg/kg p.o.) 2 or 6 h prior to s.c. injection of cyclophosphamide (CP) raised the acute toxicity of CP in male Sprague-Dawley rats by 60%. The acute LD50 was reduced from 236 mg/kg after application of CP alone to 90 mg/kg and 95 mg/kg after pretreatment with DSF 2 and 6 h prior to CP administration, respectively.

Key concepts: Disulfiram, Cyclophosphamide, Pharmacology, Toxicity, Acute toxicity, Median lethal dose, Chemistry, Medicine

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Influence of pretreatment with disulfiram (DSF) on the acute toxicity of cyclophosphamide (CP) in male Sprague-Dawley rats. — Research Paper | ScholarLens