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The effect of microinjections of clonidine into the locus coeruleus on cortical EEG in rats.

Wojciech Danysz, Wanda Dyr, Adam Płaźnik, Wojciech Kostowski

Abstract

Microinjections of clonidine into the locus coeruleus (LC) area synchronized rat cortical EEG. This effect of clonidine was attenuated by local pretreatment of rats with idazoxan, an alpha-2 adrenoceptor antagonist. The data indicate functional role of alpha-2 adrenoceptors within LC area in regulation of ceruleocortical activity, and point at the LC as one of brain targets for the sedative action of clonidine.

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Key concepts: Locus coeruleus, Clonidine, Microinjections, Idazoxan, Antagonist, Electroencephalography, Internal medicine, Endocrinology