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[Prevention of cardiovascular risk in menopause women: role of ovarian hormones].

Rosano Gm, Filippo Leonardo, Simona Ricci, Serra Gb, Sergio Lorenzo Chierchia

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Abstract

Women receiving estrogen replacement therapy after menopause have a reduced risk of cardiovascular and cerebrovascular mortality when compared to untreated controls. Estrogens are thought to protect women primarily through an effect on lipid metabolism. However estrogen-induced increase of HDL-cholesterol and decrease of total and LDL-cholesterol appear to account only in part for the protective effect of ovarian hormones. Direct effects of estrogens on the arterial wall appear to contribute to the over-all cardiovascular benefits.

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What this paper is about

Women receiving estrogen replacement therapy after menopause have a reduced risk of cardiovascular and cerebrovascular mortality when compared to untreated controls. Estrogens are thought to protect women primarily through an effect on lipid metabolism. However estrogen-induced increase of HDL-cholesterol and decrease of total and LDL-cholesterol appear to account only in part for the protective effect of ovarian hormones. Direct effects of estrogens on the arterial wall appear to contribute to the over-all cardiovascular benefits.

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Available abstract

Women receiving estrogen replacement therapy after menopause have a reduced risk of cardiovascular and cerebrovascular mortality when compared to untreated controls. Estrogens are thought to protect women primarily through an effect on lipid metabolism. However estrogen-induced increase of HDL-cholesterol and decrease of total and LDL-cholesterol appear to account only in part for the protective effect of ovarian hormones. Direct effects of estrogens on the arterial wall appear to contribute to the over-all cardiovascular benefits.

Key concepts: Menopause, Estrogen, Hormone, Medicine, Internal medicine, Endocrinology, Hormone replacement therapy (female-to-male), Cholesterol

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