[Changes of relative variables about prethrombosis state and its clinical significance in patients with pregnancy induced hypertension].

OBJECTIVE: To explore the changes of the hemorrheology coagulation and fibrinolytic system in patients with pregnancy induced hypertension (PIH). METHODS: To examine the platelet alphagranule membrane protein (GMP-140), Von-Willebrand factor (vWF), antithrombin III activity (AT-III), plasminogen activity (PLG), the activity of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in 30 non-pregnancy women, 30 normal late pregnancy women and 50 pregnancy induced hypertension women. RESULTS: In PIH group vWF [(156 +/- 23)%], GMP-140 [(23.9 +/- 3.6) microg/L], Fbg [(15.5 +/- 0.8) g/L], PLG [(141 +/- 9)%], D-Dimer [(1.42 +/- 0.32) mg/L], PAI [(9.2 +/- 0.8) kU/L] were obviously higher than those of control group. AT-III, ProC in PIH group were lower than that of the control group (P < 0.01). t-PA has no significant differences (P > 0.05). CONCLUSIONS: Prethrombotic state was shown in normal late pregnancy women. Obvious prethrombotic state was shown in patients with pregnancy induced hypertension women.