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Comparative analysis of interferon and antiviral protein messenger RNAs.

Ershov Fi, Sokolova Tm, E B Tazulakhova, А. А. Кадырова, U Kisling, A S Novokhatsky

Abstract

A comparative analysis of interferon and antiviral protein messenger RNAs was carried out. Differences in their biological activities and sedimentation coefficients were found. In RNA preparations from superinduced cells (cells treated with poly(I).poly(C) and antimetabolites) and from cells treated with interferon, messenger RNAs possesing interferon and antiviral activities were detected. The results suggest the existence of two types of mRNA (for interferon and antiviral protein, respectively) and support the hypothetic model of interferon action via an antiviral protein.

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Available abstract

Key concepts: Interferon, Messenger RNA, Antiviral protein, RNA, Biology, Protein biosynthesis, Virology, Molecular biology