2015•The Journal of Organic ChemistryRequires access

Enantioselective Synthesis of Highly Substituted Chromans via the Oxa-Michael–Michael Cascade Reaction with a Bifunctional Organocatalyst

Prasenjit Saha, Arnab Biswas, Nagaraju Molleti, Vinod K. Singh

Abstract

A highly enantioselective synthesis of chiral chroman derivatives via an oxa-Michael-Michael cascade reaction has been developed using a bifunctional thiourea organocatalyst. The products were obtained with excellent enantioselectivities (up to >99%), good yields (up to 95%), and diastereoselectivities (up to 5:1).

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Key concepts: Chemistry, Bifunctional, Enantioselective synthesis, Michael reaction, Cascade, Organocatalysis, Organic chemistry, Combinatorial chemistry