Cannabis. IV. : Smoking Test

Smoking tests of the hashish tetrahydrocannabinol, cannabidiol and cannabigerol were carried out, and the components in the smoke condensates were examined with the acid of thin-layer and gas liquid chromatography techniques. The following results were obtained ; 1) Acid-form genuine substances were decarboxylated to give the physiologically active phenols. 2) Tetrahydrocannabinol was partly converted to cannabinol (ca. 10%), but the conversion of tetrahydrocannabinol (Δ2) to Δ3-derivative was not observed. 3) Cannabidiol and cannabigerol were smoked without remarkable change in their structures. 4) A good amount of the marihuana components in the hashish cigarette were determined in the smoke condensate. The effect of the hashish smoking, therefore, seems to be represented as the combined action of tetrahydrocannabinol and cannabinol.