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[Expression and significance of Fas/APO-1 and Bcl-2 protein in human lung cancer.].

Yongxiang Yi, Xin Gan, C Lin, Xingsheng Hu

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Abstract

BACKGROUND: To investigate the role of Fas/APO-1 and Bcl-2 in oncogenesis and progression of lung cancer. METHODS: The expression of Fas/APO-1 and Bcl-2 protein were detected in 65 lung cancer tissues and 46 normal lung tissues by immunohistochemistry. RESULTS: The positive rate of Fas/APO-1 protein expression in lung cancer tissues was 56. 92 % , which was significantly lower than that in normal lung tissues (82. 61 %) ( P < 0. 01) . The positive rate of Bcl-2 protein expression was 46. 15 %. It was significantly higher than that in normal lung tissues (6. 52 %) ( P < 0. 01) . CONCLUSIONS: Both Fas/APO-1 and Bcl-2 may play an role in the oncogenesis and progression of lung cancer.

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What this paper is about

BACKGROUND: To investigate the role of Fas/APO-1 and Bcl-2 in oncogenesis and progression of lung cancer. METHODS: The expression of Fas/APO-1 and Bcl-2 protein were detected in 65 lung cancer tissues and 46 normal lung tissues by immunohistochemistry. RESULTS: The positive rate of Fas/APO-1 protein expression in lung cancer tissues was 56. 92 % , which was significantly lower than that in normal lung tissues (82. 61 %) ( P < 0. 01) . The positive rate of Bcl-2 protein expression was 46. 15 %. It was significantly higher than that in normal lung tissues (6. 52 %) ( P < 0. 01) . CONCLUSIONS: Both Fas/APO-1 and Bcl-2 may play an role in the oncogenesis and progression of lung cancer.

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Available abstract

BACKGROUND: To investigate the role of Fas/APO-1 and Bcl-2 in oncogenesis and progression of lung cancer. METHODS: The expression of Fas/APO-1 and Bcl-2 protein were detected in 65 lung cancer tissues and 46 normal lung tissues by immunohistochemistry. RESULTS: The positive rate of Fas/APO-1 protein expression in lung cancer tissues was 56. 92 % , which was significantly lower than that in normal lung tissues (82. 61 %) ( P < 0. 01) . The positive rate of Bcl-2 protein expression was 46. 15 %. It was significantly higher than that in normal lung tissues (6. 52 %) ( P < 0. 01) . CONCLUSIONS: Both Fas/APO-1 and Bcl-2 may play an role in the oncogenesis and progression of lung cancer.

Key concepts: Lung cancer, Carcinogenesis, Immunohistochemistry, Lung, Pathology, Cancer, Cancer research, Protein expression

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[Expression and significance of Fas/APO-1 and Bcl-2 protein in human lung cancer.]. — Research Paper | ScholarLens