1998•PubMedRequires access
[Role of aldose reductase inhibitors in the development of peripheral neuropathy in experimental diabetes].
Kuchmerovskaia Tm, Donchenko Gv, Klimenko Ap, Chichkovskaia Gv, Pakirbaeva Lv, Z Ia Kozitskiĭ, Efimov As
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Abstract
Streptozotocin-induced diabetes in rats is accompanied by development of diabetic complications such as neuropathies. It was shown that aldose reductase inhibitors (A1-1576, sorbinil and unithiol) administration partially normalized not only polyol pathway. Aldose reductase inhibitors partially restored Na+, K(+)-ATP-ase activity in sciatic nerve of diabetic rats and redox state of nicotinamide adenine dinucleotides. The sorbitol level increases in streptozotocin-diabetic rats as compared to control. Administration of aldose reductase inhibitors to diabetic rats is accompanied by partial reduction of sorbitol level in sciatic nerve. The results obtained confirm the important role of a dose reductase inhibitors, as antidiabetic drugs, in the improvement of diabetic neuropathy.