The natriuretic peptide family
Kazuwa Nakao, Hiroshi Itoh, Yoshihiko Saito, Masashi Mukoyama, Yoshihiro Ogawa
Abstract
Kazuwa Nakao, Hiroshi Itoh, Yoshihiko Saito, Masashi Mukoyama, Yoshihiro Ogawa
Abstract
The natriuretic peptide system is a complicated system comprising at least three endogenous peptides (atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide) and three receptors [the atrial natriuretic peptide-A receptor (guanylyl cyclase B), the atrial natriuretic peptide-B receptor (guanylyl cyclase B) and the clearance receptor]. The accumulated evidence indicates that this system is implicated in the control of blood pressure, body fluid homeostasis and vascular remodelling as cardiac hormone and local regulator.
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The natriuretic peptide system is a complicated system comprising at least three endogenous peptides (atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide) and three receptors [the atrial natriuretic peptide-A receptor (guanylyl cyclase B), the atrial natriuretic peptide-B receptor (guanylyl cyclase B) and the clearance receptor]. The accumulated evidence indicates that this system is implicated in the control of blood pressure, body fluid homeostasis and vascular remodelling as cardiac hormone and local regulator.
Key concepts: NPR2, NPR1, Natriuretic peptide, Atrial natriuretic peptide, Receptor, Internal medicine, Homeostasis, Peptide