Clinical anti laboratory slutlies

The expression of two immunohistochemical markers of neural tissue and of cutaneous sweat glands (S-100 protein and Leu-7 antigen) was studied in a group of cutaneous epithelial, mostly glandular, tumors. These antigens were detected only on sweat gland neoplasms showing both types (eccrine and apocrine) of differentiation. These results suggest that antibodies to S-100 protein and to Leu-7 antigen have a limited value in the distinction between eccrine and apocrine tumours, but they may serve as a useful adjunct for the confirmation of the glandular differentiation of cutaneous epithelial tumors. (J AM ACAD DERMATOL 1987;17:187-91.) Sweat gland neoplasms of the skin represent a distinct group of cutaneous benign and more rarely malignant epithelial tumors that display a differentiation toward structures of the sweat gland apparatus. Aside from morphologic features, these tumors also bear proper immunohistochemical characteristics that differentiate them from other epithelial (including adnexal) proliferations. The most used immunohistochemical marker in this respect is represented by carcinoembryonic antigen, which has been shown to be expressed in the skin by sweat glands and tumors arising thereof. 1.2 More recently, two new antigens have been added to the list of the immunohistochemical markers that may be used in the investigation of sweat gland