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[Two stages of contact interaction of liposomes with bimolecular lipid membranes].

Babunashvili In, A Ia Sil'bershteĭn, Nenashev Va

Abstract

Interaction of liposomes with BLM is confirmed to consist of two stages. The first stage is a semi-fusion of liposomes with BLM. On this stage the bilayer in a contact area is formed of one liposome monolayer and another one of BLM. The second stage is inclusion of liposome bilayers into BLM; it occurs some tens of minutes after the first one. It occurs either by fusion or incorporation. The fusion to incorporation ratio increases with temperature. Liposomes are incorporated in BLM asymmetrically: the contact area of the liposome bilayer is always smaller than the free one.

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Key concepts: Liposome, Monolayer, Lipid bilayer fusion, Fusion, Bilayer, Lipid bilayer, Membrane, Biophysics