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Phytohaemagglutinin (PHA)-induced transformation of peripheral blood-lymphocytes in leprosy patients.

Ghei Sk, Utpal Sengupta, G Ramu

Abstract

101 patients belonging to different types of leprosy were investigated for PHA-induced lymphocyte transformation in peripheral blood. There was a significant depression (P < 0.05) in blastogenesis in borderline (BB), borderline lepromatous (BL) and lepromatous (LL) patients. On the other hand, tuberculoid (TT) and borderline tuberculoid (BT) patients did not show any alteration in PHA-induced blastogenesis (P > 0.05) when compared to normal. The significance of these findings have been discussed.

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Key concepts: Phytohaemagglutinin, Medicine, Leprosy, Peripheral blood, Tuberculoid leprosy, Immunology, Lepromatous leprosy, Peripheral