ScholarLens Back to search
2005•Indian Journal of Pharmaceutical SciencesRequires access

Synthesis and pharmacological evaluation of some potent 2-(4-substitutedphenyl)-4,5-diphenyl-1H-imidazoles

Ayarivan Puratchikody, Sai Tejaswari Gopalakrishnan, Maruthai Nallu

Open publisher page 4 citations

Abstract

The reaction between benzil and ammonium acetate with appropriate aldehyde(s) in glacial acetic acid readily gives 2-(4-substitutedphenyl)- 4,5-diphenyl-1H-imidazole (1-10). The spectra (IR, 1 H and 13 C NMR and MS) and analytical data have supported their structures. Toxicity of 1-10 has been determined. Analgesic, antiinflammatoy, antiepileptic and locomotor activities of the compounds 1-10 have been evaluated by standard methods.

About this research paper

What this paper is about

The reaction between benzil and ammonium acetate with appropriate aldehyde(s) in glacial acetic acid readily gives 2-(4-substitutedphenyl)- 4,5-diphenyl-1H-imidazole (1-10). The spectra (IR, 1 H and 13 C NMR and MS) and analytical data have supported their structures. Toxicity of 1-10 has been determined. Analgesic, antiinflammatoy, antiepileptic and locomotor activities of the compounds 1-10 have been evaluated by standard methods.

Why it matters

OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

The reaction between benzil and ammonium acetate with appropriate aldehyde(s) in glacial acetic acid readily gives 2-(4-substitutedphenyl)- 4,5-diphenyl-1H-imidazole (1-10). The spectra (IR, 1 H and 13 C NMR and MS) and analytical data have supported their structures. Toxicity of 1-10 has been determined. Analgesic, antiinflammatoy, antiepileptic and locomotor activities of the compounds 1-10 have been evaluated by standard methods.

Key concepts: Benzil, Ammonium acetate, Acetic acid, Imidazole, Chemistry, Aldehyde, Proton NMR, Nuclear chemistry

Back to paper searchBrowse research topicsOriginal source
Synthesis and pharmacological evaluation of some potent 2-(4-substitutedphenyl)-4,5-diphenyl-1H-imidazoles — Research Paper | ScholarLens