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Chick embryonic development following exposure to ethanol and pyrazole.

Gilani Sh, Rahul Sachdev, Persaud Tv

Abstract

The mechanism of alcohol-induced dysmorphogenesis is not clear. Pyrazole is a potent inhibitor of alcohol dehydrogenase. Treatment of chick embryos at 96 h incubation with pyrazole (0.1 mg) and ethanol (0.1 ml, 40-60% v/v) enhanced the embryopathic response, compared with individual treatments. The results suggest that ethanol itself is embryotoxic.

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Key concepts: Pyrazole, Ethanol, Alcohol dehydrogenase, Incubation, Alcohol, Embryo, Chemistry, Teratology