1956•American Journal of Tropical Medicine and HygieneRequires access

Further Studies on Cross-Resistance between Pyrimethamine and Related Compounds

Joseph H. Greenberg, Howard W. Bond

Abstract

SummaryA strain of Plasmodium gallinaceum was made 800-fold resistant to pyrimethamine. The strain was found to be resistant to several other 2,4-diaminopyrimidines, chlorguanide, and a diaminotriazine at the highest dose tolerated by the chicks. These data are compared with those obtained earlier when the strain was only 64-fold resistant to pyrimethamine and these differences are discussed.

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Key concepts: Pyrimethamine, Plasmodium gallinaceum, Avian malaria, Strain (injury), Virology, Biology, Malaria, Cross-resistance