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Infection of Hela cells with a virulent and an attenuated strain of pseudorabies virus studied by electron microscopy.

F Golais, Fedor Čiampor

Abstract

Hollow-core particles, forming crystals in nuclei, prevailed in HeLa cells infected with an attenuated strain of pseudorabies virus (PRV). After infection with a virulent PRV strain, the cells contained mainly fully infectious dense-core particles. These findings might explain the lower susceptibility of HeLa and some other human cells to infection with attenuated strains of PRV as compared to virulent strains.

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Key concepts: Pseudorabies, Virulence, Virology, HeLa, Virus, Strain (injury), Biology, Electron microscope