[Ticlopidine and aspirin in the treatment of unstable angina: comparative evaluation of their effect of anti-aggregation and platelet membranes].

The study was undertaken to examine changes in ADP-induced aggregation of platelets, blood-circulating platelet aggregates, platelet phospholipids and cholesterol in patients with unstable angina depending on the therapy with disaggregatory agents. The patients from Group 1 (n = 23) received ticlopidine, 500 mg/day, in addition to antianginal therapy and heparin; those from Group 2 (n = 21) had aspirin, 320 mg/day, those from Group 3 (n = 36) took no disaggregahts. Ticlopidine was found to produce more marked effects on ADT-induced plasma platelet aggregation, in vivo reversible platelet aggregation, and reduced platelet levels of free cholesterol, as compared to aspirin.