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Comparison of the alpha-adrenergic agonists, phenylephrine and methoxamine in rabbit papillary muscles.

Siegl Pk, McNeill Jh

Abstract

The positive inotropic effects of the alpha-adrenergic agonists, phenylephrine and methoxamine were compared in isolated rabbit papillary muscles. Phenylephrine in the presence of 10(-7)M propranolol produced a greater response than methoxamine. Antagonism by phentolamine was competitive for phenylephrine and apparently, noncompetitive for methoxamine. Based upon observed maximum following frequencies, 10(-4)M methoxamine had a greater cardiac depressant effect than 10(-4) phenylephrine. It was suggested that phenylephrine with a beta-adrenergic antagonist possessed advantages over methoxamine as an agonist for studying cardiac alpha-adrenergic receptors in rabbit papillary muscles.

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Key concepts: Methoxamine, Phenylephrine, Phentolamine, Propranolol, Agonist, Internal medicine, Endocrinology, Antagonist