Pharmacological Studies of Troponoids. II. : Studies of Sympathetic Ganglion Blocking Actions of 2, 5-Diaminotropone Hydrochloride (DAT)

Sympathetic ganglion blocking actions of 2, 5-diaminotropone (DAT) were investigated and the following results were obtained. 1) In rats and cats, DAT produced a long-lasting fall of the blood pressure. 2) DAT blocked the cat superior cervical ganglion and guinea-pig hypogastric nerve ganglion. 3) DAT potentiated the contraction of cat nictitating membrane induced by electrical stimulation of the superior cervical postganglionic fiber and the contraction of guinea-pig vas deferens induced by electrical stimulation of the hypogastric postganglionic fiber. 4) On rabbit jejunum-mesentery preparation (Finkleman's preparation), DAT did not inhibit the responses induced by the electrical stimulation of postganglionic fiber. 5) DAT showed a weak atropine like action. 6) Sympathetic ganglion blocking activities of DAT were about ten times more potent than hexamethonium, and LD50 (i.v.) of DAT was less than 1/5 of that of hexamethonium.