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Inhibition of non-adrenergic transmission in the rat vas deferens by prazosin.

O Ebong, M A Zar

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Abstract

Isolated preparations of rat vas deferens were induced to contract by neurogenic and non-neurogenic stimuli, and the effect of prazosin on these contractions was investigated. Prazosin (24 microM) exerted a profound inhibitory effect on neurogenic contractions and had no significant effect on non-neurogenic contractions. These experiments indicate that prazosin is capable of interacting with the neurotransmission processes in the vas deferens to produce inhibition of transmission.

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What this paper is about

Isolated preparations of rat vas deferens were induced to contract by neurogenic and non-neurogenic stimuli, and the effect of prazosin on these contractions was investigated. Prazosin (24 microM) exerted a profound inhibitory effect on neurogenic contractions and had no significant effect on non-neurogenic contractions. These experiments indicate that prazosin is capable of interacting with the neurotransmission processes in the vas deferens to produce inhibition of transmission.

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Available abstract

Isolated preparations of rat vas deferens were induced to contract by neurogenic and non-neurogenic stimuli, and the effect of prazosin on these contractions was investigated. Prazosin (24 microM) exerted a profound inhibitory effect on neurogenic contractions and had no significant effect on non-neurogenic contractions. These experiments indicate that prazosin is capable of interacting with the neurotransmission processes in the vas deferens to produce inhibition of transmission.

Key concepts: Prazosin, Vas deferens, Medicine, Adrenergic, Neurotransmission, Inhibitory postsynaptic potential, Endocrinology, Internal medicine

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Inhibition of non-adrenergic transmission in the rat vas deferens by prazosin. — Research Paper | ScholarLens