Fluorescence Imaging of Protein Kinase C Translocation in Living Cells

The existence of multiple isozymes of protein kinase C (PKC) raised a new question of whether each PKC isozyme has a specific function ( 1 – 7 ). The activation mechanism of each PKC isozyme is clearly different among the three subgroups, conventional PKC, novel PKC, and atypical PKC, but that of each isozyme in a subgroup has not been clarified ( 1 – 8 ). Many reports have demonstrated that a certain cellular response is regulated by a specific PKC isozyme, although the molecular mechanisms of PKC function in defined cellular responses has not been clarified. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.