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1985•Southern Medical JournalRequires access

Mexiletine: Long-term Follow-up of a Patient With Prolonged QT Interval and Quinidine-Induced Torsades de Pointes

MADAELIL G. THOMAS, Thomas D. Giles

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Abstract

The use of class 1A antidysrhythmic agents in patients with or without prolonged QT intervals carries a risk of induction of polymorphic ventricular tachycardia. The class 1B antidysrhythmics have many similarities to the former group, but have different modes of action and electrophysiologic properties. Therefore, lidocaine and lidocaine-like drugs such as mexiletine may be used with relative safety in this clinical situation, as in the case we have reported, in which lidocaine and mexiletine controlled VPB in the acute stage and during long-term follow-up respectively, while quinidine induced "torsades de pointes."

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What this paper is about

The use of class 1A antidysrhythmic agents in patients with or without prolonged QT intervals carries a risk of induction of polymorphic ventricular tachycardia. The class 1B antidysrhythmics have many similarities to the former group, but have different modes of action and electrophysiologic properties. Therefore, lidocaine and lidocaine-like drugs such as mexiletine may be used with relative safety in this clinical situation, as in the case we have reported, in which lidocaine and mexiletine controlled VPB in the acute stage and during long-term follow-up respectively, while quinidine induced "torsades de pointes."

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The use of class 1A antidysrhythmic agents in patients with or without prolonged QT intervals carries a risk of induction of polymorphic ventricular tachycardia. The class 1B antidysrhythmics have many similarities to the former group, but have different modes of action and electrophysiologic properties. Therefore, lidocaine and lidocaine-like drugs such as mexiletine may be used with relative safety in this clinical situation, as in the case we have reported, in which lidocaine and mexiletine controlled VPB in the acute stage and during long-term follow-up respectively, while quinidine induced "torsades de pointes."

Key concepts: Mexiletine, Quinidine, Medicine, Torsades de pointes, Lidocaine, QT interval, Ventricular tachycardia, Antiarrhythmic agent

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Mexiletine: Long-term Follow-up of a Patient With Prolonged QT Interval and Quinidine-Induced Torsades de Pointes — Research Paper | ScholarLens