1992•PubMedRequires access
[The interrelation between the formation of oleandomycin and the resistance to it in different strains of Streptomyces antibioticus].
Andrew A. Shevchenko, A F Tyshchenko, Ryzhakova Lb, Matseliukh Bp
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Abstract
Strains, producers of oleandomycin, with different level of antibiotic-formation have been studied for their resistance to their own antibiotic. The obtained highly active strain possesses double resistance to oleandomycin and 50% higher activity. Identity of oleandomycin phosphate substances synthesized by initial and produced highly active strains is shown by the HELC method.