2014•PubMedOpen access

Calcitonin Gene-Related Peptide Regulates Cardiomyocyte Survival through Regulation of Oxidative Stress by PI3K/Akt and MAPK Signaling Pathways.

Nsini Umoh, Robin K. Walker, Richard Mark Millis, Mustafa AlRubaiee, Pandu R. Gangula, Georges E. Haddad

Abstract

/Ad.Akt(K179M) co-treatment alleviated the CGRP-increased caspase activity and -decrements in SOD-3. These findings demonstrate a CGRP negative effect on the PI3K/Akt signaling pathway and CGRP receptor-induced crosstalk between PI3K/Akt and MAPK in normal cardiomyocytes. Future studies to differentiate CGRP effects on intracellular signal transduction mechanisms in pathological conditions will elucidate the significance of CGRP in, and provide novel therapeutic targets for, heart failure.

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Key concepts: Protein kinase B, PI3K/AKT/mTOR pathway, Calcitonin gene-related peptide, MAPK/ERK pathway, LY294002, Signal transduction, Internal medicine, Endocrinology