2001•PubMedRequires access

[Docitaxol-induction apoptosis of osteosarcoma].

Lijun Peng, Z Wang, Q Wang

Abstract

OBJECTIVE: To study the growth inhibition and apoptosis induction effect of docitaxol on osteosarcoma cells. METHODS: The effect of docitaxol on osteosarcomat cell line PL-1 was examined by cell count, morphologic observation, flow cytometry (FCM) and electronmicroscopy. RESULTS: Docitaxol inhibited the growth of PL-1 in a time and dose-dependent manner. The osteosarcoma cells were blocked at G1 phase of the cell cycle. The treated cells presented features typical of apoptosis. Cells recultured shortly after being treated with docitaxol were more apt to undergo apoptosis than cells treated with docitaxol continuously. CONCLUSION: The growth inhibiting effect of docitaxol is due to its ability to induce apoptosis. It shows great potential in the treatment of osteosarcoma.

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Key concepts: Osteosarcoma, Apoptosis, Flow cytometry, Cell cycle, Cell growth, Cell culture, Cell, Cancer research