[Analysis of early, delayed phase and late cutaneous reactions to ten groups of antigens in 581 patients with allergic rhinitis].

Immediate, late phase and delayed skin reactions against ten group of allergens were investigated in 581 patients with allergic rhinitis. The wheal and flare reaction were characteristic for type 1 IgE mediated hypersensitivity reaction in human skin. This reaction develops rapidly after injection of antigen, peaks in 10-30 minutes, and then subsides within a few hours. However, careful observation for longer periods has shown that in many instances a late inflammatory response also appears at the same site and is quite different in appearance from the initial reaction. In this study, we have investigated immediate, late phase also delayed phase skin reactivity incidence of the allergic rhinitis patients.