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Proliferating cell nuclear antigen (PCNA) and nucleolar organizer regions (NORs) in benign, atypical and malignant meningiomas.

Lee Mc, Kang Mw, Yang Bs, Park Cs, Juhng Sw, Se Won Jung, Kim Jh, Kim Sh, Kang Ss, Lee Jh

Abstract

Expression of proliferating cell nuclear antigen (PCNA) and numbers of nucleolar organizer regions (NORs) were studied by immunohistochemistry and the silver staining technique in 99 meningiomas and related to histopathologic grading, recurrence and their predictive value for recurrence. The results indicated that there was a significant correlation between PCNA or AgNORs and histopathologic grading of meningiomas. Slightly higher expression of PCNA in atypical meningiomas was correlated with the increased recurrence rate; however, expression of PCNA and numbers of AgNORs in meningiomas are not reliable criteria to predict tumor recurrence.

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Key concepts: Proliferating cell nuclear antigen, Nucleolus organizer region, Grading (engineering), Immunohistochemistry, Pathology, Biology, Silver stain, Nucleolar Organizer Region