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[Effects of sulpiride isomers in the control of blood pressure in man].

Fabio Benfenati, Pietro Cortelli, M. de Camillis, Fabio Orlandi, C. Forni

Abstract

The effects of d-Sulpiride (25 mg i.v.) and 1-Sulpiride (25 mg i.v.) administration in the control of arterial blood pressure (ABP) and PRL-GH secretion have been analyzed in five normal male volunteers. It was observed a quite different action on ABP, 1-Sulpiride causing a long lasting hypotension and d-Sulpiride a short-lived hypertension. The correlation between ABP, heart rate and PRL-GH levels suggests a probable central cation for 1-Sulpiride and a possible peripheral action for d-Sulpiride effects on ABP.

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Key concepts: Sulpiride, Blood pressure, Internal medicine, Endocrinology, Heart rate, Medicine, Chemistry, Pharmacology