[About the formation of the uniform rhythm in the sinoatrial node of the heart].

Dynamic processes during the establishment of the uniform heart rhythm have been considered. It was shown that, during the establishment of the uniform rhythm as a result of mutual synchronization, the establishment of phase parities and a delay of excitation occur. The establishment of the uniform rhythm in a system of cooperating pacemakers of relaxation oscillators was studied on various mathematical models of the sinoatrial node. The formation of the uniform rhythm was investigated for dot and distributed mathematical models of the sinoatrial node, including tens of thousands of pacemakers. The influence of heterogeneity on the formation of the uniform rhythm and the dynamics of processes of the establishment and the effect of clusterization on rhythm formation in the multi-pacemaker sinoatrial node were studied. On the mathematical models of Bonhoffer-Van der Pol, Fitz Hugh, and Morris-Lecar, the dynamics of formation of the uniform rhythm in a distributed sinoatrial node was studied.