Spontaneous and stimulated lymphocyte transformation test in homozygous children with cystic fibrosis.

Spontaneous and non-specific mitogenic stimulated lymphocyte transformation tests of cellular immune function were carried out. The phytohaemagglutinin, concanavalin A and pokeweed mitogen stimulated lymphocyte transformation was significantly diminished in the group of cystic fibrosis (CF) homozygotes as compared to the controls, as an indication of the impaired reactivity of the T-lymphocytes. The spontaneous phytohaemagglutin stimulated lymphocyte transformation ratio was diminished, too.