Single dose comparison of salbutamol and a fenoterol/ipratropium combination from metered aerosols in patients with asthma.

The single dose spirometric response to a combination metered aerosol product, fenoterol/ipratropium was compared with salbutamol from a metered aerosol in ten stable asthmatics. Two puffs from the combination aerosol (fenoterol 100 micrograms and ipratropium bromide 40 micrograms/puff) were compared with two puffs of salbutamol (100 micrograms/puff). The study was a cross-over design, using a double dummy technique and was placebo controlled. All subjects had demonstrated prior reversibility and baseline FEV1, values were within 15% on each study day.