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Influence of ethanol on the antiarrhythmic activity of verapamil.

Barbara Filipek, J Krupińska, K. Zebala, Ilona Szymańska, Tadeusz Librowski, Wojciech Piekoszewski

Abstract

The aim of this work was to determine the influence of ethanol on the antiarrhythmic activity of verapamil in the model of calcium arrhythmia in rats non-dependent and dependent on ethanol. The results of the experiment show that a combined, single administration of ethanol and verapamil attenuates in a statistically significant manner the antiarrhythmic effect of verapamil. Ethanol administered repeatedly together with verapamil does not diminish the antiarrhythmic activity of verapamil.

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Available abstract

Key concepts: Verapamil, Ethanol, Pharmacology, Calcium, Chemistry, Medicine, Internal medicine, Biochemistry