2010•PubMedRequires access

[Clinicopathological significance of CD137L expression in laryngeal carcinoma].

Xiaoming Li, Xiuying Lu, Yinghui Chen

Abstract

OBJECTIVE: To study the expression of CD137L in laryngeal carcinoma, and to analyze its clinicopathological significance. METHOD: The expression of CD137L in 50 laryngeal carcinoma specimens and 9 normal laryngeal mucous tissues were detected by immunohistochemical staining. RESULT: The positive CD137L staining were found in all 50 cases of laryngeal carcinomas (100%), while its staining were negative in normal laryngeal mucous. There was significant difference between two groups (P < 0.01). The positive ratio of CD137L staining had no relationship with the factors such as age, sex and tumor site, while it had significant correlation with the pathological stage, T stage and lymph node metastasis. CONCLUSION: The expression of CD137L might play an important role in the development of laryngeal carcinomas.

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Available abstract

Key concepts: Immunohistochemistry, Laryngeal Neoplasm, Staining, Carcinoma, Stage (stratigraphy), Pathology, Pathological, Medicine