1988•Journal of Applied PhysiologyRequires access

CO binding to hemoglobin and myoglobin in equilibrium with a gas phase of low PO2 value

A Agostoni, Michele Perrella, L. Sabbioneda, U. Zoni

Abstract

The aim of this paper was to measure the binding of CO to myoglobin and hemoglobin at various PO2 values. For this purpose we have studied an "in vitro" system made up of solutions of hemoglobin and myoglobin equilibrated in two connected tonometers with the same gas phase of various PO2 and PCO. The results indicate that a significant proportion of CO is released by hemoglobin and binds myoglobin at low PO2 values (approximately 2-3 Torr), in qualitative agreement with the predictions of a previous computer simulation of the "in vivo" system.

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Key concepts: Myoglobin, Hemoglobin, Chemistry, Hemeprotein, Gas phase, Oxygen, In vivo, Analytical Chemistry (journal)