[Maternal serum matrix metalloproteinase-9 and interleukin-6 in predicting chorioamnhionitis in patients with premature rupture of membranes].

Objective To assess the potential role of maternal serum matrix metalloproteinase-9 and interleukin-6 in predicting chorioamnhionitis in patients with premature rupture of membranes (PROM). Methods Fifty women with singleton gestations PROM were studied.We excluded women with complications. Maternal serum matrix metalloproteinase-9 and interleukin-6 levels were measured by enzyme-labeled immunosorbent assay. Chorioamnhionitis was diagnosed histologically. Results Maternal serum matrix metalloproteinase-9 and interleukin-6 levels were significantly higher in women with chorioamnhionitis than in those without ( P0.01 ). Using maternal serum cutoff levels of 115.0 ng/ml for matrix metalloproteinase-9 and 68.5 ng/ml for interleukin-6, the sensitivity, specificity, and positive and negative predictive values for diagnosing chorioamnhionitis were 89.7% versus 86.2%, 71.4% versus 66.7%,81.2% versus 78.1%, and 83.3% versus 77.8%, respectively. Conclusion Maternal serum matrix metalloproteinase-9 is an accurate biochemical marker in predicting chorioamnhionitis with better sensitivity, specificity, and positive and negative predictive values than interleukin-6.